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GLP-1 and the reduction of food intake Following the demonstration that intracerebroventricular administration of GLP-1 inhibited food intake in mice and rats, treatment of animals with peripherally administered GLP-1RA was associated with reduction of food intake and weight loss (1)

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South Asia: In South Asia, India leads the demand for GLP-1 receptor agonists, supported by a large diabetic patient population and increasing healthcare access

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Byetta isnt injected once weekly

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Braunwald E

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Cardiovascular events have been adjudicated across the whole study program, and incidences of non-fatal MI, non-fatal stroke, cardiovascular death, and hospital admission for angina tended to be reduced over up to 2 years, albeit with low numbers of events (Nauck & D'Alessio 2022)

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Hence, initial clinical studies of exenatide in PD can be viewed as highly encouraging, supportive of further larger studies, and the analysis of available biomarkers in the time-dependently collected serum and CSF samples obtained from the double-blind study could well provide insight into the molecular mechanisms that underpin exenatides positive actions in PD

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