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GLP-1 medications dont cause muscle loss, but lifestyle can

48 It showed outstanding resistance to DPP-IV (half-life of 13 h in human plasma upon subcutaneous administration)

Therefore, reduced food intake primarily drives weight loss secondary to GLP1RA

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An additional annual weight loss of 4.8% total body weight (mean 4.4 kg) has been observed, with side effects including nausea, headache and dizziness [11, 16]
In a separate study, patients who lose significant weight rapidly can appear up to five years older than those who havent had comparable weight changes, says Gould