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Importantly, they emphasised that sustainable recovery is likely to depend not only on medication but also on psychological therapies and social support, as well as policy or community-level approaches to tackle societal norms and weight bias. The researchers note limitations of their study, as most of the trials included in the review had a high risk of bias and were funded by pharmaceutical companies, and they rarely included participants with a clinical diagnosis of binge eating disorder, which the researchers say limits the certainty of the findings

The result is typically severe nausea, vomiting, or both, because they stacked the side effects of rapid escalation onto a body that had not yet reached steady state at the previous dose

doi: 10.1136/bmj.j4849 10 CooperTCSimmonsEBWebbKBurnsJLKushnerRF

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