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Further investigations are needed to elucidate the effects of GLP-1RA on the disease process, joint structure and [patient reported outcomes] of OA.

doi: 10.1016/j.jad.2012.01.013 216 ZhengP.ZengB.ZhouC.LiuM.FangZ.XuX.et al

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On Day 11, peripheral organs (heart, spleen, kidney, pancreas, liver, mesenteric, perirenal and epididymal white adipose tissue, interscapular brown adipose tissue) were collected and their wet organ weights measured

The GLP-1 receptor agonists are generally well tolerated, although administration of exenatide is dose-dependently associated with nausea

GLP-1 signaling also directly downregulates proinflammatory cytokines in mucosal immune cells (55), consistent with a targeted hierarchy of mechanisms that prioritizes epithelial defense and local immune modulation over systemic immunosuppression