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Gastrointestinal side effectsincluding nausea, vomiting, and changes in food preferencescan further limit food choices and reduce protein consumption

Patients should be counselled on recognising and managing side effects, and advised to contact their GP or diabetes specialist nurse if they experience persistent symptoms or have concerns about their treatment

Without intervention, MASH can evolve into more severe liver diseases, underscoring the importance of early detection and treatment

Suppression of monosodium urate crystal-induced cytokine production by butyrate is mediated by the inhibition of class I histone deacetylases

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It is also worth noting that, despite some absolute reduction in lean mass, the proportion of body weight that is lean mass may increase overall as fat mass falls more substantially