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Understand the Alternatives: Dietary supplements might mimic the effects of GLP-1 agonists by improving insulin sensitivity and promoting insulin release

Strong needle aversion Some patients will simply not start an injection

Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea

For broader regulatory context, see FDA Peptide Reclassification 2026: What It Means for Canadian Researchers

Safety and efficacy of once-weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes over 84 weeks

To conduct this first pharmacological experiment, effective, high doses of the compounds, validated in preclinical models with metabolic alterations 33,34,35,41,42 , were selected