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Description
Diabetes, 60 (9), 2308-14 PMID: 21868791 Holst JJ (2011)

Conclusion Semaglutide has been approved by the FDA in tablet, and injection form
Cell Rep 16 , 23592372, doi:10.1016/j.celrep.2016.07.063 (2016)

Further, these treatments require medical supervision to monitor progress and address any side effects

You are wondering if adding HRT would help

Additionally, some may experience weight loss initially but reach a plateau, unable to break through a specific weight threshold