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Sulfur burps tend to be most intense during the 24 to 72 hours after injection when medication levels peak

GLP-1RAs and CVOTs Available GLP-1RAs (except for exenatide twice daily) have been examined in multicentre, double-blinded, randomised, placebo-controlled cardiovascular (CV) outcomes trials (CVOTs)

Other common gastrointestinal effects include: Vomiting (5-24% of patients) Diarrhea (8-30% of patients) Constipation (10-24% of patients) Abdominal pain or discomfort (5-20% of patients) These side effects are typically most pronounced when initiating therapy or increasing doses, and often diminish over time as the body adjusts to the medication

Diabetic cardiomyopathy is an important cardiac complication which is accompanied by cardiac hypertrophy [78]

Information supplied to their GLP-1 patients TGA is recommending that patients only fill their prescription for GLP-1 therapies if their doctor confirms that this is still the best treatment option for the specific patient