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Cleavage of SDF-1 by DPP-4 results in loss of activity (65), and consistent with this, DPP-4 inhibition in humans has been associated with enhancement of some effects which are associated with SDF-1 [increased levels of circulating endothelial progenitor cells (66) and increased distal tube sodium excretion (64)]

Medicines such as GLP-1 receptor agonists (for example, semaglutide and liraglutide) slow gastric emptying, meaning food stays in the stomach for longer

doi: 10.1007/978-3-319-41334-1_2

FIGURE 10 3.6 Validation of the expression of GLP-1 signaling-related genes in CRC tissues Subsequently, we performed protein-protein interaction network analysis among 42 genes related to GLP-1 signaling (Supplementary Figure S1) and selected top 10 genes with highest node-degree for further validation in CRC tissues (Supplementary Table S2)