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The rationale for combining them, as explored in published research, is potential additive or synergistic engagement of these separate receptor systems
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Our analysis indicated that DPP-4i treatment has a mild anti-hypertensive effect as a monotherapy and causes a significant reduction in BP when used in combined treatments

doi: 10.1186/s12199-018-0710-7 20 DaiSShuDMengFChenYWangJLiuXet al

Uneven concentrations can lead to a higher risk of nausea, vomiting, or getting an ineffective dose
