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This is relevant as the drug predominantly used off-label for IIH, acetazolamide, can be poorly tolerated

One study published in 2025 in Diabetologia looked at whether taking GLP-1 drugs were associated with worsening of retinopathy when patients had no or only mild nonproliferative diabetic retinopathy (NPDR) at initiation of treatment

11 This adverse effect may be related to GLP-1 R activation in the CNS, which can influence cerebrovascular tone and regional blood flow, potentially resulting in cerebral vasodilatation and headaches due to mechanical strain on pain-sensitive structures

While the results for many have been remarkable, the decision to start one deserves real consideration

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