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It's something like 27 more gallbladder-related events per every 10,000 patients treated per year, so it's a pretty small absolute risk. He added that the incidence of gallbladder events often increases after weight loss in general, but some studies suggest that GLP-1 drugs slow down gallbladder motility which could create a sludge that leads to gallstones (8)

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The rate of non-live births was similar between the two groups: 29.7% among women who continued GLP-1 medications 27.1% among women who discontinued them After accounting for differences in individual risk factors, the researchers found no statistically significant difference

We use these to establish a robust relationship between GLP-1R trafficking and insulin release in a manner not predicted by the standard pharmacological potency testing for cyclic adenosine monophosphate (cAMP), a primary second messenger coupling GLP-1R activation to insulin secretion 13
