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The FDA states that exenatide, the first GLP-1 receptor agonist, is being phased out as of January 2025 due to a GLP-1 scarcity

The adiponectin gene is located on chromosome 3q26, a region highly susceptible to the development of metabolic syndrome and Type 2 diabetes mellitus. Research conducted on the Pima Indians of Arizona, a population with the highest known prevalence of Type 2 diabetes, has shown low adiponectin levels are associated with insulin resistance, whereas higher concentration of adiponectin helped protect against development of Type 2 diabetes. CNIs in addition to increasing insulin resistance, induces pancreatic beta cell apoptosis if administered in large doses., resulting in decreased insulin secretion. Thus CNIs, while effective in preventing organ rejection, disrupt glucose metabolism by increasing insulin resistance and reducing insulin secretion leading to abnormalities in the glucose homeostasis (Figure 1)

Every treatment plan is prescribed and monitored by a licensed provider to ensure safety, personalization, and appropriate follow-up

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14:473 [PubMed: 24563333] 21

This approach reflects the success seen with SGLT2 inhibitors, which have demonstrated significant cardioprotective and anti-inflammatory effects in conditions such as SLE, leading to their integration into clinical practice for autoimmune diseases (83)