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As presented at the American Diabetes Association Meeting: this randomized phase 2b trial in 230 adults with overweight or obesity shows that aleniglipron, an oral small-molecule GLP1-RA, led to up to 11.3% body-weight loss compared with placebo after 36 weeks of treatment.

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A review of 80-plus studies upends the conventional wisdom.

Most of the clinical trials dont have even have a BMI requirement in the enrolment criteria