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doi: 10.3389/fendo.2026.1805015 Received 05 February 2026 Revised 06 March 2026 Accepted 12 March 2026 Published 26 March 2026 Volume 17 - 2026 Edited by Yuzuru Ohshiro, Omoromachi Medical Center, Japan Reviewed by Edward Wargent, University of Buckingham, United Kingdom Antonio Maria Labate, ASST Franciacorta, Italy Updates Copyright 2026 Alkhezi, Alfehaid, Alanezi, Alotaibi and Alshaya

These results suggested the possibility of GLP-1 as a treatment for diabetes, but limitations for therapeutic utility existed as endogenous GLP-1 had a short half-life in plasma of 1 to 2 minutes, degraded by the dipeptidyl-peptidase 4 (DPP-4) enzyme [13]

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49 GLP-1RA is primarily used for the treatment of T2DM 68 and works by mimicking the action of the naturally occurring hormone GLP-1, which is released by the intestines in response to food intake