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A recent multicenter international phase II RCT (GOLDEN-505) in noncirrhotic biopsy-proven NASH patients showed an insignificant difference in NASH resolution without fibrosis progression between the elafibranor and placebo groups at 52 weeks of treatment

Resistance training helps stimulate muscle tissue and may reduce muscle loss during weight reduction

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In some cases, dehydration from severe nausea, vomiting, or diarrhea (common early side effects of semaglutide) can strain the kidneys, especially in those with compromised kidney function