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GLB, HWR, and KRT reviewed the document and provided critical scientific feedback

If patients do not tolerate a dose during dosage escalation, consider delaying dosage escalation for 4 weeks

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One honest caveat from the data: because the Phase 2 curve had not clearly plateaued by the end of the study, the full ceiling of the effect is genuinely not yet known that is one of the questions the Phase 3 TRIUMPH program is designed to answer

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Without treatment, the infection can last a long time and, if left untreated, could permanently damage the bladder and kidneys