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It also works on another hormone called GIP

In turn, adiponectin can ameliorate NAFLD-associated liver abnormalities by regulating the oxidation of hepatic fatty acid and the activity of acetyl-CoA carboxylase and fatty acid synthase, two key enzymes involved in fatty acid synthesis (51)

Wolfgang Marik: declares no conflict of interest relevant to this study

It appears in a lot of research and in a variety of contexts

Animal data confirms this directly: retatrutide induces greater body weight losses in obese mice than tirzepatide, due to increased energy expenditure through GCGR activation