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In a recent trial, semaglutide led to a 20% reduction in major adverse cardiovascular events (MACE) in patients []

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Methods This study is a single-arm, post hoc, observational analysis of the randomized, double-blind, placebo-controlled SUSTAIN-6 cardiovascular outcomes trial (NCT01720446)

Combining topiramate with semaglutide requires careful medical oversight due to potential interactions and overlapping effects on appetite and metabolism