what are glp-1 weight loss drugs leave users low on key nutrients, study finds How GLP-1 medications are transforming

S7B, GLP-1RA intervention was associated with a reduction in HDL when compared to placebo (MD = 0.02

doi: 10.1186/S12933-020-01163-9 16 KimuraG

Whether orforglipron's effects on bone health are net positive (through receptor-mediated bone protection) or net negative (through sustained caloric deficit and weight loss reducing mechanical loading on bones) will need to be determined through long-term surveillance studies

Patel et al

specifically examined patients with MASLD cirrhosis and type 2 diabetes, finding that GLP-1 receptor agonist initiation was linked to reduced risk of unfavorable liver outcomes including hepatic decompensation events and mortality from any cause (aHR: 0.78, 95%CI: 0.68-0.90) relative to non-users, suggesting potential benefits even in advanced liver disease populations [58]

But heres the kicker: the big benefits like beating diabetes or dodging heart attacks can take years to show up