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lixisenatide), LEADER (Liraglutide Effects and Action in Diabetes: Evaluation of cardiovascular outcome Results

The most commonly reported adverse events (observed in greater than 5% of clinical trial participants) were nausea, diarrhea, vomiting, constipation, abdominal pain, dyspepsia, injection-site reactions, fatigue, hypersensitivity reactions, eructation, hair loss and gastroesophageal reflux disease

Adipose tissue (body fat) plays an active role in hormone metabolism

Bottom line: Oral GLP-1 supplements have a more substantiated evidence base than patches

For SGLT-2 inhibitors no studies regarding placental transfer were found

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