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Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial. Nature medicine vol

Against those benchmarks, oral agents currently sit at a level of efficacy that is meaningful but measurably lower

While those medications have shown meaningful results for many patients, retatrutide builds on that foundation by addressing additional metabolic factors that influence long-term weight management

Sanchez-Garrido, M

These drugs have been used to help people control their diabetes and lose weight in recent years

While phentermine can be a useful weight loss tool, its not recommended as a first-line treatment