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The novel peptide is biased towards GLP-1R agonism versus GCGR with a 3-4 fold reduced potency at the GLP-1R compared to native GLP-1 and around an 8-fold reduced potency at the GCGR compared to native glucagon

However, in juvenile but not adult human islets, exendin-4 stimulated calcineurin/NFAT signaling and enhanced expression of proliferation-promoting factors such as NFATC1, FOXM1, and CCNA1 [557]

The relationship between dose and heart rate is clear enough that reducing the dose will reduce the cardiovascular effect proportionally

This helps address the insulin resistance that can develop during the menopause transition, which may break the cycle of cravings and energy crashes

Dehydration from gastrointestinal side effects (nausea, vomiting, diarrhoea) may contribute to dizziness and requires adequate fluid intake

JAMA 2022;327:534-45.ArticlePubMedPMC 129