evaluate the pharmaceutical company trulicity on glp 1 ADA: Lilly's tops Ozempic at keeping patients compliant, real-world data show Trulicity (dulaglutide) for the Treatment

In studies, most nausea, diarrhea and vomiting occurred when people increased their dose but the effects generally decreased over time

Endocrinology 158: 21242133, 2017

Cost-Effectiveness Analysis: Cost per Pound Lost (Estimated): Oral Semaglutide (Rybelsus): Average weight loss: 10 pounds (for 250 lb person) Cost: $900-$1,000/month for 6 months = $5,400-$6,000 Cost per pound lost: $540-$600 Injectable Semaglutide (Compounded from TrimRx): Average weight loss: 37 pounds (for 250 lb person) Cost: $199/month for 16 months = $3,184 Cost per pound lost: $86 Injectable Tirzepatide (Compounded from TrimRx): Average weight loss: 56 pounds (for 250 lb person) Cost: $349/month for 18 months = $6,282 Cost per pound lost: $112 Value Comparison: Hidden Costs: Oral Semaglutide: No injection supplies needed (saves $20-30/month) May require acid reflux medication if SNAC causes irritation Potential need for additional weight loss interventions if not effective Injectable Medications: Injection supplies usually included or inexpensive Sharps container ($5-10 one-time) Potential anti-nausea medication ($10-30/month if needed) Insurance Variables: If your insurance covers Rybelsus with a $25-$50 copay, it may seem like an attractive option

Exclusion criteria included: (1) animal-only studies without translational relevance

Wegovy is the brand approved for chronic weight management, while Ozempic is approved for type 2 diabetes

Mice were subcutaneously injected with the triple agonist and immediately followed by fasting for a 4 h period