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Constipation: common but manageable Constipation is frequently reported with GLP-1 therapy and may worsen with: Low fibre intake Reduced food intake Inadequate hydration A sedentary lifestyle Helpful measures may include: Adequate water intake Fibre-rich fruits and vegetables Walking or light physical activity Isabgol or fibre supplementation if medically appropriate To reduce nausea, many patients find relief by switching to lighter regional Indian meals and smaller portions during the first few weeks

References: Charbonnel B, Cariou B (2011): Pharmacological management of type 2 diabetes: the potential of incretin-based therapies

Cellular Repair & Anti-Aging RETATRUTIDE 20mg Retaklik (retatrutide) is a triple agonist targeting the GLP-1, GIP, and glucagon receptors, designed to support effortless weight control and improve glucose balance

A meta-regression analysis of GLP-1RA CVOT showed that the magnitude of HbA1c lowering, but not body weight (BW) loss, was associated with the prevention of renal outcomes [24]

Similar results were also manifested in the rat model as in the mouse model (Zhang et al., 2015

I plan on doing many more of these on every peptide that matters