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Similarly, trials examining the reverse scenarioadding a GLP-1 agonist to DPP-4 inhibitor therapyhave shown that whilst some glycaemic improvement occurs, it is primarily attributable to the GLP-1 agonist itself, with the DPP-4 inhibitor contributing minimally

So while the raw numbers show headaches in trial participants, the signal was not strong enough relative to placebo to warrant special labeling

Aug 11 2023;13(8)doi:10.3390/life13081732 Mahler SA

The American College of Obstetricians and Gynecologists (ACOG) similarly advises that GLP-1 receptor agonist medications, including tirzepatide, should generally be discontinued before conception due to limited safety data in human pregnancy

As mentioned above, Wegovy is a subcutaneous injection

Exenatide sensitizes insulin-mediated whole-body glucose disposal and promotes uptake of exogenous glucose by the liver