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So far, research trials havent prompted regulatory agencies to approve these substances or convinced companies to invest in further development

[8] [22] In December 2024, the FDA revised the indication for tirzepatide (as Zepbound) to include the treatment of moderate to severe obstructive sleep apnea

therefore, additional randomized trials and well-controlled comparative effectiveness studies are needed

But convenience and safety are not the same thing, and that distinction has become critically important

In T2D mice, oral administration of Lactobacillus casei increased the abundance of Bacteroidetes, Bifidobacterium , and Lactob acillus, and butyrate production increased, which stimulated GLP-1 secretion (53)