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The latest GLP-1 agonist medication, tirzepatide (trade name Mounjaro), seems to be the most effective GLP-1 agonist for weight loss yet, resulting in substantial and sustained reductions in body weight in a 2022 trial

Enhanced insulin secretion : GIP and GLP-1 stimulate insulin release through partially distinct intracellular mechanisms

Patients should contact their healthcare provider if experiencing persistent vomiting (more than 24 hours), severe diarrhea, inability to maintain oral hydration, symptoms of orthostatic hypotension, or very low urine output

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Liraglutide, a long-acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes

Post-marketing serious cardiovascular, cerebrovascular, and vascular adverse events were reported in temporal association with sildenafil use and include myocardial infarction, sudden cardiac death, ventricular arrhythmia, cerebrovascular hemorrhage, transient ischemic attack, hypertension, subarachnoid and intracerebral hemorrhages or intracranial bleeding, and pulmonary hemorrhage