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Additionally, GLP-1 analogs reduced energy expenditure, with only tirzepatide showing a significant decrease in the respiratory quotient (RQ) in MC4R KO mice

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Liraglutide (3.0 mg, daily subcutaneous injection, n=22) or semaglutide (1.0 mg, weekly subcutaneous injection, n=18) was started 74.5 (51.0, 108.3) months after surgery following a weight regain of 14.7 (10.3, 19.6)%

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GLP-1 drugs cause rapid weight loss, which for some users comes with unexpected and less desirable side effects, such as an altered sense of smell and taste, sagging skin, wrinkles, muscle mass loss, and bad breath