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GIP may enhance weight loss by directly targeting its receptor in the central nervous system to regulate appetite, enhancing GLP-1s anorectic action, and reducing drug-induced nausea in order to improve the tolerability of and compliance to GLP-1 receptor agonists [45]

And that is a lot of conditions

If the scale stalls for two weeks but your clothes are looser, thats not a plateau

GLP-1RAs seem to protect dopamine producing neurons which are the cells lost in Parkinsons

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By transferring ownership (and technology) of these sites, Novo effectively expedited capacity increases that otherwise might require years to build