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Cardiovascular Effects Dose-dependent increases in heart rate were observed with retatrutide: Heart rate increases peaked at approximately 24 weeks Gradually declined thereafter while remaining elevated above baseline This pattern is similar to that observed with other GLP-1 receptor agonists[4] The clinical significance of these heart rate changes requires further evaluation in larger and longer-term studies

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Repatha is used to lower high cholesterol alongside dietary changes and to reduce the risk of major cardiovascular events in those at increased risk for these events, such as death from cardiovascular disease, heart attack, stroke, angina requiring hospitalization, or certain types of heart surgery
