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A 2021 trial published in the New England Journal of Medicine (Lundgren et al.) found that combining exercise with GLP-1 treatment led to better long-term weight maintenance than either approach alone

Usually in the first one to two weeks, and again briefly after each dose increase, as your gut adjusts to the medication

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Non-arteritic anterior ischemic optic neuropathy Recent studies have raised concerns about a potential association between GLP-1 RAs and non-arteritic anterior ischemic optic neuropathy