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Cardiovascular Risk Reduction# Recommendation : Semaglutide Reason : SELECT demonstrated 20% MACE reduction with semaglutide 2.4 mg in 17,604 patients

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Additionally, when PEN2 is specifically knocked out in the gut, the ability of metformin to promote insulin and GLP-1 secretion is impaired (Ma et al., 2022)

These medications include semaglutide (Ozempic, Wegovy, Rybelsus), liraglutide (Victoza, Saxenda), and dulaglutide (Trulicity)

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