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This is bad news for overweight humans with a sweet tooth

Despite their significant clinical potential, they are associated with certain limitations, including suboptimal pharmacokinetics and patient adherence challenges, necessitating the development of advanced drug delivery systems to optimize efficacy and improve compliance

doi: 10.1038/s42255-023-00931-7 55 ZhangQDelessaCTAugustinRBakhtiMColldenGDruckerDJet al

Optimal food choices on tirzepatide include lean proteins, vegetables, and whole grains while minimizing high-fat and high-sugar foods that can exacerbate nausea

the caveat is that without further long-term studies, there is no certainty that this rate of gastric emptying will ever normalize whether these patients discontinue treatment or not

Short-acting agents like exenatide often cause more gastroparesis (slow gastric emptying), while long-acting ones like dulaglutide may be better tolerated