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Alosetron should be stopped after 4 weeks if symptoms still exist, even if the dosage is increased to 1 mg twice a day (61)
Practical considerations for lighter individuals include potentially stronger gastrointestinal side effects at each dose level, faster onset of appetite suppression, and the possibility that 4 to 8 mg may be your effective maintenance range rather than 12 mg

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Am J Physiol Renal Physiol (2010) 298(1):F17786

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