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It's a fillip for new Novo Nordisk chief executive Mike Doustdar, who took the helm last year with a clear remit to defend the GLP-1-based weight loss and diabetes business from rivals like Eli Lilly, as well as knock-off versions of semaglutide that sidestep the company's intellectual property (IP).

The work of Lebrun et al now adds an important piece to this puzzle by describing a critical and previously unrecognized role for the gut-derived hormone glucagon-like-peptide 1 (GLP-1) in the regulation of intestinal inflammation

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It is a big indication (5% of western population) and growing rapidly

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