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Janssens J, Peeters TL, Vantrappen G, Tack J, Urbain JL, De Roo M, et al

All patients were required to have continuous enrollment of at least 12 months before cohort entry and meet eligibility criteria for one of the five cohort studies defined below (study design diagrams depicted in Supplementary Figs

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It is a series of medical decisions based on the patients progress, tolerance, risks, goals, and health markers