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The medication is FDA-approved for patients with type 2 diabetes, established cardiovascular disease, and those with chronic kidney disease and type 2 diabetes

Mechanistic studies exploring CNS interactions, such as GLP1 signalling within the HPA axis and dopaminergic circuits, may elucidate the biological pathways underlying the psychiatric effects observed in clinical populations

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The absence of additive benefit across most clinical outcomes in the comparison between GLP-1RA plus SGLT2i and GLP-1RA monotherapy suggests that the observed effect may be predominantly driven by GLP-1RA alone, rather than a synergistic effect of the combination

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