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Richard et al., 2015

Many people experience withdrawal-like symptoms that are common across the GLP-1 class, and the timeline of symptom emergence follows the pharmacokinetic clearance curve

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Similarly, Figures 5G and H show that PNP-1-10-0.05 Sema-1.8 mg/mL hydrogel resulted in sustained glucose lowering compared to the bolus injection, maintaining efficacy across the cohort

Salomons GS, Jakobs C, Wyss M

While such a proximal-distal loop might indeed exist, it cannot be ruled out that while fewer in number, L-cells in the upper intestine are sufficient for the rapid induction of GLP-1 secretion following nutrient intake [[316], [317], [318]]