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When exposed to endotoxin (LPS), IL-1, or IL-6, these cells rapidly increase GLP-1 secretion in both mice and humans, highlighting GLP-1 as a key communicator between the gut, immune system, and systemic inflammation

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The gastrointestinal effects typically diminish as the body adjusts to the medication, usually within 4-8 weeks

doi: 10.1016/j.cmet.2020.06.014

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Vivek Bansal, MD MPH, Triple Board-Certified Endocrinologist and Founder of The EnLyv Clinics in Bridgewater, NJ