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The subsequent phase 3 trial of tirzepatide demonstrated more effective reductions in the glycated hemoglobin levels and body weight, along with greater overall improvements in the lipid profile compared to semaglutide in patients with T2DM, elevating incretin therapeutic agents to a new level (112)

Does fasting affect GLP-1 levels

Injectable GLP-1 drugs also must be stored in the fridge, which may put off some people who find this reduces privacy and convenience, compared with taking a pill

GLP-1R has been densely found in the choroid plexus, suggesting the possibility it may play a role in sodium transport and cerebrospinal fluid (CSF) production [102]
21, article 172, 2022, Lincoff, A
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