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[DOI] [PubMed] [Google Scholar] 12.Moreau JA, Zinsmeister AR, Melton LJ, 3rd, DiMagno EP

Its concurrent engagement of GLP-1R, GIPR, and GCGR distinguishes it structurally and pharmacologically from both selective GLP-1R agonists such as semaglutide and dual GLP-1R/GIPR agonists such as tirzepatide

Gastrointestinal side effects lead some patients to discontinue treatment, and weight regain after stopping therapy is common

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GLP-1RAs make a direct protective impact on the endothelium by the GLP-1R-dependent AMPK/Akt/eNOS pathway [105]

For bodybuilders, maintaining a lean physique while building muscle mass is crucial