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Employing HITI for in vivo knock-in of large DNA fragments, we designed a guide RNA (gRNA) targeting exon 14 of the Alb gene (sgAlb-E14), which has demonstrated efficient ectopic gene integration via genome editing 20

J Biol Chem 280: 2229722307

Drinking large amounts with food dilutes digestive enzymes and adds volume to an already slow-emptying stomach, increasing nausea and bloating

Protein kinase A mediates glucagon-like peptide 1-induced nitric oxide production and muscle microvascular recruitment

Exenatide (20 g/kg/day) treatment inhibited brain TNF- levels, which were induced by intracerebroventricular injection of STZ [89]

Gradual escalation allows the body to adjust to GLP-1 receptor activation while maintaining tolerability