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Patients with existing conditions like hiatal hernia, peptic ulcer disease, or Barrett's esophagus face higher risk of severe reflux escalation on GLP-1 therapy

That speed reflects both the urgency around obesity treatment in America and the strength of the clinical data behind the pill

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Waiting means delaying obesity treatment by 1824 months

Regarding gastric emptying, injectable GLP-1RA generally produces a more pronounced and sustained delay, whereas oral semaglutide shows a modest, early-phase effect that attenuates at steady state [74]

Variants in the GLP1R gene (such as rs6923761) and the GIPR gene (rs1800437) can alter receptor sensitivity, meaning some individuals experience more pronounced metabolic shiftsand potentially greater dizzinesswhen starting therapy, while others tolerate the same dose smoothly