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The nausea is generally most pronounced during the first few days after injection and often diminishes with subsequent doses

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The drug is also a "fully biased" GLP-1 receptor agonist, meaning it preferentially activates cyclic adenosine monophosphate (cAMP) signaling over the beta-arrestin pathway

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This mechanism differs completely from GLP-1 drugs, which directly activate receptors in the gut and brain rather than stimulating hormone release from the pituitary

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