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Diabetes itself increases NAION risk, creating particularly dangerous situations when patients take GLP-1 medications that multiply already elevated baseline risk

Use of a GLP-1RA can assist remission from early-stage disease and provide sustained benefits throughout the natural history of the disease, including compatible use with other classes of glucose-lowering agents

Further it is mandatory to conduct the above said positive immunologic test and this result should be considered a Presumed Positive or Non-Negative Result

In addition, the dosing schedule is to help minimize any chance of gastrointestinal distress, including severe nausea

doi: 10.1056/nejmoa2511774

The peptide cycle planning guide discusses how to structure protocols to optimize outcomes, and the same principles of nutritional support apply during semaglutide use