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FDA Expands Wegovy Indication to Liver Disease (MASH) Expanding Beyond Weight Loss Wegovy (semaglutide) has received FDA approval to treat metabolic-associated steatohepatitis (MASH) in adults with moderate-to-advanced fibrosis, marking the first GLP-1 therapy approved for serious liver disease

2 with the model of exendin-9-39-bound to the GLP-1R ECD (PDB: 3C5T) docked to the density

Our studies show that GLP-1 receptor agonists strongly activate the hypothalamic pituitary adrenal (HPA) axis the system that produces stress hormones such as cortisol in humans and corticosterone in preclinical models

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doi: 10.1177/1403494810394717 [DOI] [PubMed] [Google Scholar] 19
