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Most interestingly, hybrids 14 , 22 and 23 showed an improved efficacy compare to the native peptide 1 (Fig

linagliptin is an exception, as it is primarily excreted via the bile and does not require renal dose adjustment

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[12] Adverse effects [edit] Preclinical, phase I, and phase II clinical trials indicated that tirzepatide exhibits adverse effects similar to those of other established GLP-1 receptor agonists, such as dulaglutide (sold as Trulicity) and semaglutide (sold as Wegovy, Ozempic, and Rybelsus)

A specific gut microbiota dysbiosis of type 2 diabetic mice induces GLP-1 resistance through an enteric NO-dependent and gut-brain axis mechanism

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