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Subepithelial myofibroblasts expressing GLP-2R increase IGF-1 mRNA expression and secretion in response to GLP-2 stimulation, and genetic deletion of the intestinal epithelial IGF-1 receptor abolishes GLP-2-induced crypt cell proliferation in mice (69, 70)

A coach who understands these medications knows to start with lower intensity, progress gradually, prioritize compound movements that maximize stimulus in shorter sessions, and adjust on days when the side effects are hitting hard

Therefore, GLP-1R stimulation has been linked to changes in functional connectivity, the disruption of which has been implicated in the development of various mental disorder symptoms, such as anhedonia