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In PTC, activated SEs modulate the high expression of proto-oncogenes, such as ALOX5, ELF3 and PLXNC1, which are related to tumour invasion
consequently, increased endometrial resistance to BMP2 could contribute to the low HOXA10 and HOXA11 levels in the endometrium of women with UFs (Sinclair et al., 2011

Starting dose also mattershigher initial doses may show faster appetite suppression, while lower doses allow gentler adaptation with fewer side effects

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PMID: 84 LeeKAbrahamSCleaverR

Nat Med 27, 10791087 (2021)